Can PARP inhibitors be used therapeutically in toxicology?
Yes, PARP inhibitors have therapeutic potential beyond oncology. In toxicology, they are being explored for their ability to protect tissues from damage caused by excessive inflammation and oxidative stress. For instance, in cases of acute brain injury or myocardial infarction, PARP inhibitors may reduce tissue damage by preventing energy depletion and necrosis. However, the systemic inhibition of PARP requires careful consideration due to potential side effects, highlighting the importance of targeted delivery and dosing strategies.
