What are the toxicological implications of PARP activation?
Overactivation of PARP can deplete cellular NAD+ and ATP levels, leading to necrosis. This is particularly relevant in toxicological studies involving oxidative stress and chemical-induced cell damage. Excessive PARP activation has been implicated in conditions like ischemia-reperfusion injury and neurodegenerative diseases. Understanding how toxicants affect PARP activity can provide insights into their potential to cause cellular energy crisis and contribute to cell death pathways.
