PARP inhibitors have garnered attention in both pharmacology and toxicology. By inhibiting PARP activity, these compounds prevent the repair of DNA damage, leading to the accumulation of DNA breaks. This can induce cytotoxicity, especially in cells deficient in other DNA repair pathways, such as BRCA1 or BRCA2 mutations. In toxicology, PARP inhibitors are used to study the effects of impaired DNA repair mechanisms and investigate potential therapeutic windows for exploiting DNA damage in cancer therapy.
