In cases of acute alcohol poisoning, the role of ADHs becomes particularly important. High levels of ethanol can saturate these enzymes, leading to the accumulation of unmetabolized alcohol in the bloodstream. This can result in central nervous system depression, respiratory failure, and even death. Similarly, the ingestion of toxic alcohols like methanol and ethylene glycol requires prompt medical intervention to inhibit ADH activity, often using antidotes like fomepizole or ethanol, to prevent the formation of toxic metabolites.
