Genetic polymorphisms in the genes encoding ADHs can lead to significant variations in enzyme activity among individuals. For example, certain variants of the ADH1B gene are associated with faster metabolism of ethanol to acetaldehyde. This rapid conversion can lead to higher levels of acetaldehyde, resulting in adverse effects like flushing and increased risk of alcohol-related cancers. Conversely, slower metabolizers may experience prolonged intoxication and different patterns of alcohol-related harm.
