Detecting non genotoxic carcinogens is challenging due to their indirect mechanisms of action. Standard genotoxicity assays like the Ames test may not identify these compounds. Therefore, alternative methods are utilized:
In Vivo Studies: Long-term animal studies can reveal carcinogenic potential through observation of tumor development over time. Biomarker Analysis: Identifying biomarkers associated with inflammation, oxidative stress, and other processes can help detect non genotoxic carcinogens. Epigenetic Screening: Techniques to detect epigenetic changes can be useful in identifying these carcinogens.
