How can PPARs be targeted for therapeutic purposes?
PPAR agonists have been developed as therapeutic agents for metabolic disorders. PPAR-alpha agonists, such as fibrates, are used to lower triglyceride levels, while PPAR-gamma agonists, like thiazolidinediones, improve insulin sensitivity in type 2 diabetes. These therapies highlight the potential benefits of modulating PPAR activity, although they must be balanced against potential adverse effects.
