What are the challenges in studying PPARs in toxicology?
One major challenge in studying PPARs is the species-specific responses to PPAR activation, which complicates risk assessment. Rodent models often exhibit different responses compared to humans, necessitating careful extrapolation of data. Additionally, there is a need for better understanding of the molecular mechanisms underlying PPAR-mediated toxicity and the development of more selective ligands to minimize side effects.
