Controlling prion contamination is difficult due to their resistance to conventional decontamination methods. Standard procedures like autoclaving or chemical disinfectants may not be sufficient. Instead, a combination of methods, including extended autoclaving at higher temperatures, use of specific chemical agents like sodium hydroxide, and incineration, is recommended for decontaminating prion-infected materials. Developing more effective decontamination protocols is an active area of research in toxicology.
