How Do ABC Transporters Affect Drug Metabolism and Toxicity?
ABC transporters significantly influence drug metabolism and toxicity by affecting the absorption, distribution, and excretion of drugs. For example, they can limit the oral bioavailability of drugs by pumping them back into the intestinal lumen or facilitate their excretion through bile and urine. This activity can protect tissues from toxic insults but also complicate therapeutic strategies by reducing drug concentrations at target sites.
