What is the Significance of ABC Transporters in Drug Resistance?
The ability of ABC transporters to pump out a broad spectrum of drugs makes them key players in drug resistance. For instance, ABCB1, also known as P-glycoprotein, is infamous for its role in cancer cells where it leads to chemotherapy resistance by expelling anticancer drugs. Understanding the mechanisms of these transporters can aid in the development of inhibitors that might enhance drug retention and efficacy in resistant cells.
