phosphodiesterase inhibitors

How Do Phosphodiesterase Inhibitors Work?

PDEIs work by inhibiting the breakdown of cAMP and cGMP, which results in elevated levels of these cyclic nucleotides within cells. This action enhances signal transduction pathways that lead to various biological effects. For instance, increased cGMP levels in smooth muscle cells lead to muscle relaxation and vasodilation, which is why PDEIs are often used to treat conditions like erectile dysfunction and pulmonary hypertension.

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