What are the Common Types of Phosphodiesterase Inhibitors?
There are several types of PDEIs, each targeting different subtypes of the phosphodiesterase enzyme. Some of the most commonly used include: - PDE5 Inhibitors: Used primarily for erectile dysfunction and pulmonary hypertension, their mechanism involves increasing cGMP concentrations in smooth muscle cells. - PDE4 Inhibitors: These are primarily used for their anti-inflammatory effects in conditions like COPD and psoriasis. - PDE3 Inhibitors: Utilized in heart failure treatment due to their ability to increase cardiac contractility and cause vasodilation.
