What are the Toxicological Concerns with Phosphodiesterase Inhibitors?
The use of PDEIs can lead to several _adverse effects_. The most common side effects include headaches, dizziness, and gastrointestinal disturbances. More serious toxicological concerns involve cardiovascular effects such as hypotension and arrhythmias, particularly in individuals with pre-existing heart conditions. Additionally, drug interactions can exacerbate these effects, especially when PDEIs are combined with nitrates or alpha-blockers.
