PXR not only modulates drug metabolism but also influences the body's response to environmental toxins and carcinogens. By upregulating detoxification pathways, PXR helps mitigate the toxic effects of harmful substances. However, its broad ligand specificity can sometimes lead to adverse drug interactions and increased toxicity. For instance, the induction of multiple drug-metabolizing enzymes may result in the bioactivation of procarcinogens, thereby enhancing their carcinogenic potential.
