How is 8-Oxoguanine detected in toxicological studies?
Detection of 8-oxoguanine in toxicological studies is commonly achieved through techniques such as high-performance liquid chromatography (HPLC), mass spectrometry, and immunohistochemistry. These methods allow for the quantification and localization of 8-oxoguanine lesions in DNA, facilitating the assessment of oxidative stress levels and potential toxic exposure in biological samples.
