What are the mechanisms of repair for 8-Oxoguanine?
Cells have evolved repair mechanisms to address the mutagenic threat posed by 8-oxoguanine. The primary pathway involves the base excision repair (BER) mechanism. The enzyme 8-oxoguanine glycosylase (OGG1) recognizes and excises the damaged base from the DNA. Subsequent steps involve the removal of the sugar-phosphate backbone and insertion of the correct base to restore the DNA sequence.
