What are the mutagenic consequences of 8-Oxoguanine?
8-Oxoguanine is mutagenic primarily because it can pair with adenine during DNA replication, leading to G:C to T:A transversion mutations. This mispairing results in genetic mutations that can disrupt normal cellular functions and promote oncogenesis. The mutagenic nature of 8-oxoguanine underscores its importance as a target for DNA repair systems and as a biomarker for evaluating mutagenic potential in toxicological assessments.
