What challenges do these alternative methods face?
Despite their advantages, alternative methods encounter several challenges:
- Validation and acceptance: Regulatory agencies require rigorous validation of these methods to ensure that they provide reliable and reproducible results. The validation process can be lengthy and complex.
- Complexity of human biology: While organ-on-a-chip and 3D bioprinting offer advanced modeling capabilities, replicating the full complexity of human biology remains a significant challenge.
- Integration with existing data: Combining new methods with existing animal data to create a comprehensive toxicological profile is a complex task that requires sophisticated data management and analysis strategies.
