Management of spironolactone toxicity primarily focuses on addressing hyperkalemia. Mild cases may be treated with dietary potassium restriction and discontinuation of the drug. In more severe cases, medical treatments such as calcium gluconate, sodium bicarbonate, or insulin with glucose may be administered to stabilize cardiac membranes and shift potassium intracellularly. Hemodialysis may be necessary for life-threatening hyperkalemia or in patients with significant renal impairment.
