Are there any long-term toxicological concerns with spironolactone use?
Long-term use of spironolactone has been associated with certain adverse effects, such as gynecomastia, menstrual irregularities, and sexual dysfunction, due to its anti-androgenic properties. Additionally, animal studies have suggested a potential risk of carcinogenicity, although the clinical significance in humans remains uncertain. Regular monitoring and individualized risk assessment are recommended for long-term users of spironolactone.
