PBPK modeling is crucial in toxicology for several reasons: 1. Risk Assessment: It helps in assessing the potential risks posed by chemical exposures to humans and wildlife. 2. Dose-Response Relationship: PBPK models provide insights into the dose-response relationship, allowing for better understanding of toxicokinetics. 3. Inter-Species Extrapolation: These models facilitate the extrapolation of data from animal studies to humans, which is essential for regulatory purposes. 4. Individual Variability: PBPK models can incorporate variability between individuals due to factors like age, gender, disease state, and genetic differences. 5. Regulatory Compliance: Regulatory agencies often require PBPK models for the approval of new drugs and chemicals, ensuring they are safe and effective.
