What is Physiologically Based Pharmacokinetic (PBPK) Modeling?
Physiologically Based Pharmacokinetic (PBPK) modeling is a mathematical modeling technique used in toxicology and pharmacology to predict the absorption, distribution, metabolism, and excretion (ADME) of synthetic or natural chemical substances in humans and other animal species. It involves the use of mathematical representations of the physiological processes governing the fate of chemicals within the body, providing a detailed simulation of how substances move through different compartments such as blood, liver, kidneys, and other tissues.
