What are the Challenges in Studying Nuclear Receptors?
Studying nuclear receptors poses several challenges:
Complex Signaling Pathways: Nuclear receptors often interact with multiple signaling pathways, making it difficult to isolate their specific effects. Species Differences: There can be significant differences in nuclear receptor activity between species, complicating the extrapolation of animal data to humans. Low-Dose Effects: Some toxicants can have significant effects at very low doses, which are challenging to detect and study. Mixture Effects: Humans are exposed to mixtures of chemicals, and the combined effects on nuclear receptors are often unknown.
