What are the Clinical Implications of CYP1A2 Variability?
The variability in CYP1A2 activity has significant clinical implications. For extensive or ultra-rapid metabolizers, standard doses of drugs metabolized by CYP1A2 may be less effective, necessitating dose adjustments. Conversely, poor metabolizers may experience increased drug exposure and a higher risk of adverse effects. Drug-drug interactions can also occur if one medication affects the activity of CYP1A2, altering the metabolism of another drug.
