While ADIs are a valuable tool in toxicology and risk assessment, they have certain limitations. For instance, they are typically based on animal studies, which might not fully replicate human responses. The safety factors used to derive ADIs are somewhat arbitrary and may not cover all possible interspecies and intraspecies variations. Additionally, ADIs do not account for cumulative or synergistic effects of multiple chemical exposures, an important consideration given the complex nature of human diets and environments.
