In the context of toxicology, CYP1A2 plays a critical role in the bioactivation of procarcinogens, such as polycyclic aromatic hydrocarbons and heterocyclic amines, which are found in tobacco smoke and charred meats. The enzyme converts these compounds into reactive intermediates that can bind to DNA, potentially leading to mutations and cancer. Understanding the activity of CYP1A2 can help in assessing individual susceptibility to chemical-induced toxicities and carcinogenesis.
