Several factors can affect the activity of CYP1A2. Genetic polymorphisms can result in different levels of enzyme activity among individuals, classified as poor, intermediate, extensive, or ultra-rapid metabolizers. Environmental factors such as diet, smoking, and exposure to certain chemicals can also induce or inhibit CYP1A2 activity. For instance, smoking is known to induce CYP1A2, leading to increased metabolism of drugs like caffeine, which may require dose adjustments.
