The formation of DNA adducts is often an early step in the process of chemical carcinogenesis. If not repaired, DNA adducts can lead to mutations that may cause cancer. The body has mechanisms to repair DNA damage, such as the nucleotide excision repair pathway. However, if the damage is extensive or the repair mechanisms are overwhelmed or defective, the risk of cancer increases. Therefore, the presence of DNA adducts is a concerning marker for potential carcinogenic exposure and subsequent disease development.
