What are the Implications of Drug-Drug Interactions with CYP450 Enzymes?
Drug-drug interactions involving CYP450 enzymes are a significant concern in toxicology. Many drugs can act as inhibitors or inducers of CYP450 enzymes, altering the metabolism of co-administered drugs. For instance, the antibiotic rifampicin is a potent inducer of CYP3A4, potentially decreasing the plasma concentration of drugs metabolized by this enzyme, such as oral contraceptives. Conversely, ketoconazole is a CYP3A4 inhibitor, which can increase the levels and toxicity of co-administered drugs metabolized by this enzyme. Understanding these interactions is vital for predicting and managing adverse drug reactions.
