Understanding CYP450 enzymes is crucial in toxicology for several reasons. First, they are responsible for the metabolic activation and detoxification of many xenobiotics, including drugs, environmental chemicals, and dietary compounds. This means that variations in CYP450 enzyme activity can significantly affect an individual's susceptibility to the toxic effects of these substances. Additionally, some CYP450 enzymes can convert prodrugs into their active forms, influencing the pharmacological and toxicological outcomes.
