How do Environmental Factors Influence CYP450 Enzyme Activity?
Environmental factors, such as diet, smoking, and exposure to pollutants, can modulate CYP450 enzyme activity. For example, compounds found in cruciferous vegetables can induce CYP1A2 activity, while smoking is known to induce several CYP450 enzymes, including CYP1A2 and CYP2E1. Additionally, exposure to certain environmental pollutants can lead to the induction or inhibition of specific CYP450 enzymes, affecting the metabolism of other xenobiotics and potentially leading to toxic outcomes.
