How do Genetic Variations Affect CYP450 Enzyme Activity?
Genetic polymorphisms in CYP450 enzymes can lead to interindividual variability in drug metabolism. These polymorphisms can result in different metabolic phenotypes: poor, intermediate, extensive, and ultra-rapid metabolizers. For example, individuals with certain genetic variations in the CYP2D6 gene may metabolize drugs more slowly or more quickly than expected, affecting drug efficacy and risk of toxicity. Personalized medicine approaches often consider these genetic polymorphisms to optimize drug therapy and minimize adverse effects.
