What are the Implications of Transporter Inhibition?
The implications of transporter inhibition are vast. It can lead to increased systemic exposure to toxicants, altered drug-drug interactions, and unexpected adverse effects. Understanding these interactions is critical in risk assessment and the development of safer therapeutic interventions. For example, the inhibition of the P-glycoprotein transporter, which is responsible for the efflux of many drugs and toxicants, can lead to increased brain penetration and neurotoxicity.
