Why is Transporter Inhibition Important in Toxicology?
Transporter inhibition can significantly affect the toxicity profile of a compound. By inhibiting transporters, the absorption, distribution, and excretion of a toxicant can be altered, potentially leading to increased tissue accumulation and enhanced toxic effects. For instance, inhibiting efflux transporters in the liver could reduce the excretion of toxic compounds, leading to hepatic accumulation and toxicity.
