What are the Key Signaling Pathways Involving TNFR1?
Upon TNF-α binding, TNFR1 undergoes a conformational change that triggers several downstream signaling pathways. The two most well-known are the NF-κB and MAPK pathways.
- The NF-κB pathway is essential for regulating immune and inflammatory responses. Activation of this pathway by TNFR1 can lead to the transcription of genes involved in inflammation, cell proliferation, and survival.
- The MAPK pathway, which includes ERK, JNK, and p38 MAP kinases, can mediate responses such as apoptosis, differentiation, and stress responses.
These pathways highlight the role of TNFR1 in modulating responses to environmental toxins, drugs, and other chemical exposures.
