In the context of drug toxicity, TNFR1 can influence the balance between therapeutic effects and adverse reactions. Certain drugs, especially those targeting immune modulation or cancer, can inadvertently activate TNFR1 pathways, leading to toxic side effects like hepatotoxicity, nephrotoxicity, or systemic inflammation. Understanding TNFR1's role can help in designing drugs that minimize these risks by selectively modulating TNFR1-related pathways.
