Tumor Necrosis Factor Receptor 1 (TNFR1) is a member of the TNF receptor family and plays a crucial role in mediating the effects of the pro-inflammatory cytokine, Tumor Necrosis Factor alpha (TNF-α). TNFR1 is a transmembrane receptor that, upon binding with TNF-α, can activate several intracellular signaling pathways that influence cell survival, apoptosis, inflammation, and immune responses. TNFR1 is expressed in many cell types, making it a pivotal element in various physiological and pathological processes, especially in the context of toxicology.
