What are the limitations of using ALT as a biomarker?
While ALT is a valuable indicator of liver injury, it has some limitations. ALT levels can fluctuate due to non-liver related factors, such as muscle damage, making it less specific to liver damage. Additionally, ALT levels may not rise significantly in chronic liver diseases, potentially leading to an underestimation of liver injury. Therefore, ALT should be used in conjunction with other diagnostic markers and clinical assessments for a more comprehensive evaluation.
