What are the toxicological implications of NPC1 and NPC2 dysfunction?
Defects in NPC1 and NPC2 can lead to the accumulation of lipids, resulting in cellular toxicity. This accumulation is particularly harmful in neurons and hepatocytes, leading to conditions such as liver dysfunction and neurodegenerative diseases. In toxicology studies, assessing the impact of environmental toxins on the expression and function of NPC1 and NPC2 provides insight into their potential to exacerbate lipid accumulation and cellular damage.
