Individuals with PDD may have a compromised ability to metabolize xenobiotics, which are foreign compounds introduced to the body. This includes drugs, environmental toxins, and dietary substances. The impaired conversion of pyruvate can lead to a buildup of lactic acid and other metabolites, potentially causing lactic acidosis. This condition can be exacerbated by certain drugs or chemicals that inhibit mitochondrial activity, such as valproic acid or alcohol.
