Currently, there is no cure for PDD, but treatment focuses on managing symptoms and preventing complications. Dietary interventions, such as a ketogenic diet, can help by providing an alternative energy source that bypasses the need for pyruvate conversion. Additionally, supplements like thiamine and lipoic acid may support residual enzyme activity. In the context of toxicology, avoiding known mitochondrial toxins and optimizing metabolic control are key strategies in managing the condition.
