What is ER-Associated Degradation and its Role in Toxicology?
ER-associated degradation (ERAD) is a process by which the ER identifies and targets misfolded proteins for degradation via the proteasome. This process is crucial for maintaining protein quality control within the ER. Disruption of ERAD can exacerbate ER stress and has been implicated in various diseases and conditions related to toxic exposure, including neurodegenerative diseases and liver disorders.
