Epigenetics refers to changes in gene expression without altering the underlying DNA sequence. These changes can be induced by environmental factors, including exposure to toxicants. Epigenetic modifications, such as DNA methylation and histone modification, can affect how genes are turned on or off, influencing an individual's response to toxins. Epigenetic changes can also be heritable, potentially impacting future generations. Understanding the role of epigenetics in toxicology can provide insights into the long-term effects of chemical exposure and potential interventions.