What is the Role of CYP Enzymes in Environmental Toxicology?
CYP enzymes also play a vital role in environmental toxicology by metabolizing environmental pollutants and toxins. For instance, CYP1A1 and CYP1B1 are involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs), which are found in tobacco smoke and charred foods. The metabolic activation of these compounds by CYP enzymes can lead to the formation of reactive intermediates that can bind to DNA and cause mutations, contributing to carcinogenesis.
