Treatment of valproic acid toxicity focuses on supportive care and specific interventions to mitigate the toxic effects. Key approaches include:
Discontinuation of valproic acid and supportive care to maintain vital functions Administration of intravenous carnitine to enhance the metabolism of valproic acid Activated charcoal may be administered if the patient presents within a few hours of ingestion Correction of metabolic disturbances, such as acidosis and hyperammonemia In severe cases, hemodialysis may be necessary to rapidly reduce serum valproic acid levels
