What Role Do Gene Products Play in Detoxification?
Detoxification is a critical process in toxicology, and gene products are essential players. Enzymes such as glutathione S-transferases (GSTs), UDP-glucuronosyltransferases (UGTs), and sulfotransferases (SULTs) are involved in phase II metabolic reactions, which conjugate toxic substances to make them more water-soluble and easier to excrete. Gene expression levels and the functionality of these enzymes can vary dramatically between individuals, influencing their capacity to detoxify harmful substances.
