What role do MAPKs play in apoptosis and cell survival?
MAPKs can have both pro-apoptotic and pro-survival roles, depending on the context and specific pathway involved. The JNK and p38 pathways are often associated with apoptotic signaling, particularly in response to cellular stress and DNA damage. Conversely, the ERK pathway is generally linked to cell survival and proliferation, although it can also contribute to apoptosis under certain conditions. The balance between these pathways can determine the fate of a cell exposed to toxic agents.
