physicochemical properties

What Role Do These Properties Play in Distribution?

After absorption, a substance's distribution within the body is also dictated by its physicochemical properties. For example:
Partition Coefficient (log P): This property indicates how a substance distributes between aqueous and lipid phases, which is crucial for understanding its movement between different body compartments.
Protein Binding: Substances that bind extensively to plasma proteins may have limited distribution to tissues.

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