What role does Fas (CD95) play in drug-induced liver injury?
Drug-induced liver injury (DILI) is a significant concern in toxicology, and Fas (CD95) has been identified as a critical mediator in this process. Hepatocytes, the main liver cells, express high levels of Fas, making them susceptible to Fas-mediated apoptosis. Certain drugs can exacerbate Fas signaling, leading to liver cell death and subsequent liver damage. This mechanism is particularly relevant in the context of acetaminophen toxicity, where Fas-mediated pathways contribute to the extent of liver injury.
